Donor Molecules Vastly Improves Precision Genome Enhancing

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sourui-koza

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of a variety of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating a variety of injections, and customarily requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by a variety of fold for longer edits.

We describe troubleshooting methods that let persistently excessive modifying efficiencies ensuing, as an illustration, in as rather a lot as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the most effective metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

sourui-koza
sourui-koza

Recombinant Vav 1 Oncogene (VAV1)

4-RPC213Mu01
  • EUR 576.96
  • EUR 278.40
  • EUR 1833.60
  • EUR 691.20
  • EUR 1262.40
  • EUR 462.00
  • EUR 4404.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Vav 1 Oncogene expressed in: E.coli

Proto-Oncogene Vav (VAV1) Antibody

20-abx141277
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

Proto-Oncogene Vav (VAV1) Antibody

20-abx000854
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Proto-Oncogene Vav (VAV1) Antibody

abx011903-100ug 100 ug
EUR 493.2

Proto-Oncogene Vav (VAV1) Antibody

20-abx012888
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Proto-Oncogene Vav (VAV1) Antibody

abx239377-100ug 100 ug
EUR 661.2

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC

4-PAC213Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Biotinylated

4-PAC213Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), Cy3

4-PAC213Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), FITC

4-PAC213Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), HRP

4-PAC213Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), PE

4-PAC213Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC

4-PAC213Mu01-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Biotinylated

4-PAC213Mu01-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Biotin.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), Cy3

4-PAC213Mu01-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with Cy3.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), FITC

4-PAC213Mu01-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with FITC.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), HRP

4-PAC213Mu01-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with HRP.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), PE

4-PAC213Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with PE.

Mouse Vav 1 Oncogene (VAV1) Protein

20-abx168844
  • EUR 811.20
  • EUR 326.40
  • EUR 2464.80
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Vav 1 Oncogene (VAV1) Protein

20-abx167017
  • EUR 828.00
  • EUR 343.20
  • EUR 2548.80
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Proto-Oncogene Vav (VAV1) Protein

20-abx263391
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Human), APC-Cy7

4-PAC213Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Vav 1 Oncogene (VAV1) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC213Mu01-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Vav 1 Oncogene (VAV1). This antibody is labeled with APC-Cy7.

Human Vav 1 Oncogene(VAV1) ELISA Kit

QY-E04499 96T
EUR 433.2

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

abx333478-100ul 100 ul
EUR 560.4

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx329104
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Vav 1 Oncogene Phospho-Tyr160 (VAV1 pY160) Antibody

20-abx326674
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Vav 1 Oncogene Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx327138
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Proto-Oncogene Vav (VAV1) ELISA Kit

abx595617-96tests 96 tests
EUR 764.4

Human Proto-oncogene vav (VAV1) ELISA Kit

abx384219-96tests 96 tests
EUR 1093.2

Bovine Proto- oncogene vav, VAV1 ELISA KIT

ELI-51386b 96 Tests
EUR 1113.6

Human Proto- oncogene vav, VAV1 ELISA KIT

ELI-51387h 96 Tests
EUR 988.8

Mouse Proto- oncogene vav, Vav1 ELISA KIT

ELI-17706m 96 Tests
EUR 1038

Proto-Oncogene Vav Phospho-Tyr174 (VAV1 pY174) Antibody

20-abx012571
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti-VAV1 Antibody

A00691-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for VAV1 Antibody (VAV1) detection. Tested with WB in Human, Mouse, Rat.

Rabbit VAV1 oncogene ELISA kit

E04V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit VAV1 oncogene ELISA kit

E04V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human)

4-PAE929Hu02
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3)

Vav 3 Oncogene (VAV3) Antibody

20-abx101251
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

20-abx101252
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Vav 3 Oncogene (VAV3) Antibody

20-abx133365
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Vav 3 Oncogene (VAV3) Antibody

abx433439-200ul 200 ul
EUR 460.8

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC

4-PAE929Hu02-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Biotinylated

4-PAE929Hu02-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Biotin.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), Cy3

4-PAE929Hu02-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with Cy3.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), FITC

4-PAE929Hu02-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with FITC.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), HRP

4-PAE929Hu02-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with HRP.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), PE

4-PAE929Hu02-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with PE.

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu01
  • EUR 980.16
  • EUR 386.40
  • EUR 3345.60
  • EUR 1195.20
  • EUR 2270.40
  • EUR 732.00
  • EUR 8184.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Recombinant Vav 3 Oncogene (VAV3)

4-RPE929Hu02
  • EUR 980.16
  • EUR 386.40
  • EUR 3345.60
  • EUR 1195.20
  • EUR 2270.40
  • EUR 732.00
  • EUR 8184.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Vav 3 Oncogene expressed in: E.coli

Anti-Vav antibody

STJ96227 200 µl
EUR 236.4
Description: Rabbit polyclonal to Vav.

Vav Polyclonal Antibody

ES7488-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody

ES7488-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Vav from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Vav Polyclonal Antibody

ABP56489-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

Vav Polyclonal Antibody

ABP56489-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Vav from Human, Mouse, Rat. This Vav antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y174

HRP-Goat Anti-Rabbit Secondary Antibody

A12004
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Vav 3 Oncogene (VAV3) Polyclonal Antibody (Human), APC-Cy7

4-PAE929Hu02-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Vav 3 Oncogene (VAV3). This antibody is labeled with APC-Cy7.

Rabbit Anti-Human Vav1 Polyclonal Antibody, Phospho-Tyr174

CPB-700RH 100 ul
EUR 670.8

VAV1 Vav 1 Guanine Nucleotide Exchange Factor Human Recombinant Protein

PROTP15498 Regular: 10ug
EUR 380.4
Description: VAV1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (189-565a.a) and having a molecular mass of 46.8kDa.

Human VAV1 oncogene ELISA kit

E01V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human VAV1 oncogene ELISA kit

E01V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human VAV1 oncogene ELISA kit

E01V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse VAV1 oncogene ELISA kit

E03V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse VAV1 oncogene ELISA kit

E03V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse VAV1 oncogene ELISA kit

E03V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat VAV1 oncogene ELISA kit

E06V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog VAV1 oncogene ELISA kit

E08V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig VAV1 oncogene ELISA kit

E07V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig VAV1 oncogene ELISA kit

E07V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig VAV1 oncogene ELISA kit

E07V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat VAV1 oncogene ELISA kit

E02V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat VAV1 oncogene ELISA kit

E02V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat VAV1 oncogene ELISA kit

E02V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey VAV1 oncogene ELISA kit

E09V0079-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey VAV1 oncogene ELISA kit

E09V0079-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey VAV1 oncogene ELISA kit

E09V0079-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey VAV1 oncogene in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated

A12001
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Human Vav 3 Oncogene (VAV3) Protein

20-abx069657
  • EUR 1345.20
  • EUR 493.20
  • EUR 4468.80
  • EUR 1629.60
  • EUR 910.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Vav 3 Oncogene (VAV3) Protein

20-abx069658
  • EUR 1345.20
  • EUR 493.20
  • EUR 4468.80
  • EUR 1629.60
  • EUR 910.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anti-VAV1 Antibody

A30436 100ul
EUR 476.4
Description: Rabbit Polyclonal VAV1 Antibody. Validated in ELISA, IF and tested in Human, Mouse, Rat.

anti- VAV1 antibody

FNab09377 100µg
EUR 702
Description: Antibody raised against VAV1

Anti-VAV1 antibody

PAab09377 100 ug
EUR 494.4

Anti-VAV1 antibody

STJ11100612 50 µl
EUR 344.4
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Anti-Vav1 antibody

STJ96228 200 µl
EUR 236.4
Description: Rabbit polyclonal to Vav1.

Anti-VAV1 antibody

STJ96406 200 µl
EUR 236.4
Description: Rabbit polyclonal to VAV1.

Anti-VAV1 antibody

STJ117302 100 µl
EUR 332.4
Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Vav1 Polyclonal Antibody

ABP52691-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Vav1 from Human, Mouse, Rat. This Vav1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav1 around the non-phosphorylation site of Y174

Vav1 Polyclonal Antibody

ABP52691-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Vav1 from Human, Mouse, Rat. This Vav1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav1 around the non-phosphorylation site of Y174

Vav1 Polyclonal Antibody

ABP52691-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Vav1 from Human, Mouse, Rat. This Vav1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav1 around the non-phosphorylation site of Y174

VAV1 Polyclonal Antibody

ABP52772-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of VAV1 from Human, Mouse, Rat. This VAV1 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y160

VAV1 Polyclonal Antibody

ABP52772-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of VAV1 from Human, Mouse, Rat. This VAV1 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y160

VAV1 Polyclonal Antibody

ABP52772-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of VAV1 from Human, Mouse, Rat. This VAV1 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Vav around the non-phosphorylation site of Y160

Vav1 Polyclonal Antibody

ES3690-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Vav1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Vav1 Polyclonal Antibody

ES3690-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Vav1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Water-Pipe Smoking Publicity Deregulates a Set of Genes Related to Human Head and Neck Most cancers Growth and Prognosis

  • Water-pipe smoking (WPS) is popping into in all probability essentially the most well-liked type of tobacco use among the many many many youth, notably contained in the Coronary heart East, altering cigarettes quickly and turning into a important danger of tobacco dependancy worldwide. Smoke from WPS accommodates comparable toxins as these current in cigarette smoke and is linked instantly with quite a lot of sorts of cancers together with lung and head and neck (HN) carcinomas.
  • Nonetheless, the underlying molecular pathways and/or goal genes accountable for the carcinogenic course of are nonetheless unknown. On this research, human widespread oral epithelial (HNOE) cells, NanoStringPanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain response (qRT-PCR) evaluation had been utilized to hunt out differentially expressed genes (DEG) modulated by WPS.
  • In silico evaluation was carried out to analysis the have an effect on of those genes in HN most cancers affected specific particular person’s biology and consequence. We discovered that WPS can induce the epithelial-mesenchymal transition (EMT: hallmark of most cancers development) of HNOE cells.
  • Additional considerably, our evaluation of NanoString revealed 23 genes deregulated beneath the have an effect on of WPS, accountable for the modulation of cell cycle, proliferation, migration/invasion, apoptosis, sign transduction, and inflammatory response.
  • Further evaluation was carried out utilizing qRT-PCR of HNOE WPS-exposed and unexposed cells supported the reliability of our NanoString data.
  • Furthermore, we exhibit these DEG to be upregulated in most cancers in distinction with widespread tissue. Utilizing the Kaplan-Meier evaluation, we seen a big affiliation between WPS-deregulated genes and relapse-free survival/full survival in HN most cancers victims.
  • Our findings level out that WPS can modulate EMT together with a set of genes which could possibly be instantly concerned in human HN carcinogenesis, thereby affecting HN most cancers victims’ survival.

A pilot research on the genetic fluctuate of Mycobacterium tuberculosis tough strains from tuberculosis victims contained in the Littoral area of Cameroon

Background: The re-emergence of tuberculosis (TB) worldwide, compounded by multi-drug resistance (MDR) of the causative brokers constitutes a big situation to the administration of the illness. Speedy analysis and correct stress identification are pivotal to the administration of the illness. This pilot research investigated the genetic fluctuate of Mycobacterium tuberculosis tough (MTBC) strains from TB victims contained in the Littoral area of Cameroon together with their resistance to rifampicin (RIF).

Victims and methods: This was a cross sectional hospital-based research carried out between January and December 2017 and together with 158 isolates from sputum smear constructive of us [105 (66.5%) males and 53 (33.5%) females]. Sputum samples had been examined utilizing Xpert MTB/RIF, adopted by customized on Lowenstein-Jensen medium. Isolates had been additional subjected to molecular characterization utilizing IS6110 typing, deletion evaluation and spoligotyping.

Outcomes: 13 (8.8%) of the 147 isolates with susceptibility outcomes accessible had been proof in the direction of RIF. Drug resistance occurred in 5/50 (10%) feminine in contrast with 8/97 (8.2%) male (OR, 0.81; 0.25-2.62; p = 0.764), and there was no crucial distinction all by the age ranges (p = 0.448). Nonetheless, RIF resistance was related (OR, 0.18, 95%CI, 0.05-0.69; p = 0.023) with beforehand handled victims [(4/14 (28.6%)] in contrast with new ones [9/133 (6.8%)].

The 150 acknowledged lineages included amongst others 54 (36%) Cameroon, 18 (12%) UgandaI, 32 (21.3%) Haarlem, 17 (11.3%) Ghana, 9(6%) West African 1, 7(4.7%) Delhi/CAS, 4 (2.7%) LAM and three (2%) UgandaII. Of the 150 isolates, a really highly effective cluster was the Cameroon SIT 61, with 43(28.7%) isolates. Six (35.3%) of the 17 UgandaI sub-lineage had been RIF resistant (OR, 9.58; 95%CI, 2.74-33.55, p = 0.001).

Conclusion: The cosmopolitan Littoral area presents with an enormous Mycobacterium tuberculosis (MTB) strains fluctuate and the UgandaI sub-lineage attainable related to RIF resistance. Understanding the unfold of this clade by way of surveillance will improve TB administration contained in the area.

Conserved Patterns in Developmental Processes and Phases, Somewhat than Genes, Unite the Extremely Divergent Bilateria

  • Bilateria are the predominant clade of animals on Earth. Regardless of having developed all kinds of physique plans and developmental modes, they’re characterised by widespread morphological traits.
  • By default, researchers have tried to hyperlink clade-particular genes to those traits, thus distinguishing bilaterians from non-bilaterians, by their gene content material.
  • Right here we argue that it’s moderately organic processes that unite Bilateria and set them aside from their non-bilaterian sisters, with a much less advanced physique morphology.
  • To check this speculation, we in contrast proteomes of bilaterian and non-bilaterian species in an elaborate computational pipeline, aiming to seek for a set of bilaterian-specific genes. Regardless of the restricted confidence of their bilaterian specificity, we nonetheless detected Bilateria-specific practical and developmental patterns within the sub-set of genes conserved in distantly associated Bilateria.
  • Utilizing a novel multi-species GO-enrichment methodology, we decided the practical repertoire of genes which can be broadly conserved amongst Bilateria. Analyzing expression profiles in three very distantly associated mannequin species- melanogasterD. rerioand C. elegans-we discover attribute peaks at comparable levels of improvement and a delayed onset of expression in embryos.
  • Specifically, the expression of the conserved genes seems to peak on the phylotypic stage of various bilaterian phyla.
  • In abstract, our research illustrate how improvement connects distantly associated Bilateria after tens of millions of years of divergence, pointing to processes doubtlessly separating them from non-bilaterians.
  • We argue that evolutionary biologists ought to return from a purely gene-centric view of evolution and place extra give attention to analyzing and defining conserved developmental processes and intervals.

The efficacy of chemotherapeutic drug mixtures could also be predicted by concordance of gene response to the only brokers

Figuring out the expression of genes in response to totally different courses of chemotherapeutic medication might enable for a greater understanding as to which can be used successfully together. Within the current research, the human colorectal most cancers cell line HCT116 was cultured with equi-active concentrations of a sequence of anti-cancer brokers.

Gene expression profiles had been then measured by whole-genome microarray. Though every drug induced a novel signature of gene expression in tumour cells, there have been marked similarities between sure medication, even in these from totally different courses. For instance, the antimalarial agent artesunate and the platinum-containing alkylating agent, oxaliplatin, produced a really related mRNA expression sample in HCT116 cells with ~14,000 genes being affected by the 2 medication in the identical manner.

Moreover, the general correlation of gene responses between two brokers might predict whether or not their use together would result in a better or lesser impact on cell quantity, decided experimentally, than predicted by single agent experiments. The outcomes indicated that even when working by totally different mechanisms, combining medication that provoke an analogous transcriptional response might represent the best choice for figuring out drug-combination methods for the remedy of most cancers.

 

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